期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 9, 期 21, 页码 7282-7286出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1ob06133j
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资金
- Department of Science and Technology (DST), New Delhi [DST/SR/S1/OC-65/2008]
- DBT [BT/PR10092/BRB/10/585/2007]
- DST-PURSE
- Council of Scientific and Industrial Research (CSIR), New Delhi
A single-step amino acid-catalyzed diastereoselective three-component synthesis of optically pure highly functionalized spiro[5,5]undecane-1,5,9-triones preferentially over the four stereoisomers was accomplished in very good yields with > 99% ee/de. Preliminary cell culture-based in vivo screening on these molecules revealed that cis-1aca and cis-1jca are better lead compounds for HIV-1 treatment than the known antiretroviral drug azidothymidine (AZT).
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