期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 9, 期 1, 页码 83-85出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0ob00843e
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We report on the design, synthesis and assessment of a novel biaryl-linked (BArL) molecular probe for the exploration of low-abundant target proteins for bioactive compounds based on the activity based protein profiling (ABPP) approach. Surprisingly, the performance of the BArL probe was better than that of the stepwise tagging approach that is considered to be the most effective method used in ABPP study.
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