期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 9, 期 9, 页码 3154-3157出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0ob01038c
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资金
- National Science Council, Taiwan [NSC 99-2323-B-038-001, NSC 98-2113-M-038-002-MY2]
- Department of Health, Taiwan [DOH99-TD-C-111-004]
In an attempt to mimic the 3,4,5-trimethoxyphenyl-Z-stilbene moiety of combretastatin A-4, a series of N-aryl-5,6,7-trimethoxyindoles were synthesized via copper-catalyzed Ullmann-type N-arylation through the corresponding 5,6,7-trimethoxyindole and aryl halides. These synthesized compounds demonstrated potent antiproliferative activity providing a novel skeleton for potent tubulin polymerization inhibitors.
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