4.6 Article

Organocatalytic asymmetric Michael-type reaction between beta,gamma-unsaturated alpha-keto ester and alpha-nitro ketone

期刊

ORGANIC & BIOMOLECULAR CHEMISTRY
卷 9, 期 23, 页码 7997-7999

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ROYAL SOC CHEMISTRY
DOI: 10.1039/c1ob06191g

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  1. European Commission [FP7-201431]
  2. PolyU Internal Grant DA [A-PD0X]

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A Michael-type reaction of beta,gamma-unsaturated alpha-keto ester and alpha-nitro ketone was established. With a thiourea catalyst derived from cinchona alkaloid, the reactions afford products in 47-94% yields with 68-96% ee.

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