期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 8, 期 15, 页码 3464-3471出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c002668a
关键词
-
资金
- NSFC [20873179]
- MOST [2007CB935902]
The combination of the readily available chiral bisphosphine ligand Difluorphos with [Ir(COD)Cl](2) in THF resulted in a highly efficient catalyst system for asymmetric hydrogenation of quinolines at quite low catalyst loadings (0.05-0.002 mol%), affording the corresponding products with high enantioselectivities (up to 96%), excellent catalytic activities (TOF up to 3510 h(-1)) and productivities (TON up to 43000). The same catalyst was also successfully applied to the asymmetric hydrogenation of trisubstituted pyridines with nearly quantitative yields and up to 98% ee. In these two reactions, the addition of I-2 additive is indispensable; but the amount of I-2 has a different effect on catalytic performance.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据