期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 8, 期 12, 页码 2859-2867出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c003588b
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资金
- Department of Science and Technology (DST), New Delhi [DST/SR/S1/OC-65/2008]
- Council of Scientific and Industrial Research (CSIR), New Delhi
A practical and sustainable chemical process for the synthesis of highly substituted tetrahydro-isobenzoluran-1,5-diones was achieved for the first time through asymmetric cascade Michael-aldol reaction of 4-hydroxy-3-alkyl-5H-furan-2-ones with alkyl vinyl ketones in the presence of a catalytic amount of L-proline or 9-amino-9-deoxyepiquinine/TCA. In this article, we discovered for the first time the asymmetric synthesis of privileged bicyclic lactones through kinetic resolution and show the synthetic application to pharmaceuticals and natural products synthesis.
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