期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 8, 期 3, 页码 564-575出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/b918755c
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资金
- Spanish Ministerio de Ciencia e Innovacion [CTQ2007-61704/BQU, CTQ2006-08256]
- Generalitat de Catalunya [2009SGR-733, 109]
Improved methodologies are provided to synthesize (1R,2S)-2-aminocyclobutane-1-carboxylic acid derivatives and their incorporation into beta-peptides of 2-8 residues bearing different N-protecting groups. The conformational analysis of these oligomers has been carried out by using experimental techniques along with theoretical calculations. This study shows that these oligomers adopt preferentially a strand-type conformation in solution induced by the formation of intra-residue six-membered hydrogen-bonded rings, affording cis-fused [4.2.0]octane structural units that confer high rigidity on these beta-peptides. Moreover, all of them are prone to self-assemble producing nano-sized fibres, as evidenced by TEM, AFM and SPFM, and, in some instances, they also form gels. These techniques and molecular modelling allowed us to suggest an aggregation model for the assembly structures in which a parallel molecular-arrangement is preferred and the conformation is similar to that observed in solution. According to this model, both hydrogen-bonding and hydrophobic interactions would account for formation of the assemblies.
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