期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 8, 期 15, 页码 3405-3417出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c004490c
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资金
- National Institutes of Health, National Institute of General Medical Science (NIGMS) [NIH R01-GM76320]
- David and Lucille Packard Foundation
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM076320] Funding Source: NIH RePORTER
The synthesis of enantiopure N-benzylidene nitrones of N-hydroxy-alpha-amino acids and their incorporation using standard Fmoc-based peptide chemistry into solid-supported peptide chains is described. Deprotection and resin cleavage affords N-terminal peptide hydroxylamines, which are the key substrates for chemoselective ligations with C-terminal peptide alpha-ketoacids. This general route is applicable to a variety of different N-terminal residues and provides a general approach to the solid phase synthesis of peptide hydroxylamines.
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