期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 8, 期 10, 页码 2323-2326出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c003092a
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资金
- Deutsche Forschungsgemeinschaft [SFB 803]
- Fonds der Chemischen Industrie (FCI)
Naturally occurring nucleoside antibiotics such as muraymycins represent promising lead structures for the development of novel antibacterial agents. A concise synthesis of 5 '-deoxy muraymycin derivatives has been developed. The key step was the highly stereoselective asymmetric hydrogenation of suitable didehydro amino acid precursors, providing unique nucleosyl amino acid structures.
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