期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 8, 期 6, 页码 1399-1405出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/b924272d
关键词
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资金
- National Natural Science Foundation of China [20772091]
- Tianjin Municipal Science & Technology Commission [07JCDJC04700]
A general method for the one-pot, three-component Strecker reaction of ketones was developed using Bronsted acids as organocatalysts. A series of alpha-aminonitriles were obtained in good to excellent yields (79-99%). A preliminary extension to a catalytic enantioselective three-component Strecker reaction of ketones (up to 40% ee) is also described.
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