4.6 Article

Gold-catalysed room-temperature cycloisomerisation of alkynes and unactivated enolisable ketones

期刊

ORGANIC & BIOMOLECULAR CHEMISTRY
卷 8, 期 13, 页码 2918-2922

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ROYAL SOC CHEMISTRY
DOI: 10.1039/c003473h

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资金

  1. University of Birmingham
  2. EPSRC [EO/F031254]
  3. Birmingham Science City
  4. EPSRC [EP/F031254/1] Funding Source: UKRI
  5. Engineering and Physical Sciences Research Council [EP/F031254/1] Funding Source: researchfish

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The cycloisomerisation of simple keto-alkynes proceeds at room temperature under the mild conditions of gold catalysis. Bicyclic fused and spiro compounds can be obtained by overall 5-exo and 6-exo carbon-carbon bond-forming cyclisations.

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