期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 8, 期 20, 页码 4682-4689出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0ob00267d
关键词
-
资金
- Australian Postgraduate Award
- Institute for Molecular Bioscience
- University of Queensland
- Australian Research Council
A Streptomyces sp. isolated from a shallow water sediment sample collected off Heron Island, Australia, afforded three new polyketide macrolactams, heronamides A-C (1-3). Structures were assigned to the heronamides on the basis of detailed spectroscopic analysis, chemical derivatization and biosynthetic considerations. A plausible biosynthetic pathway is proposed in which key carbocyclic ring transformations proceed via an unprecedented synchronized tandem electrocyclization. This biosynthesis provides a framework for the assignment of complete relative configurations across all heronamides, and inspires an attractive biomimetic strategy for future total syntheses. Heronamide C elicits a dramatic and reversible non-cytotoxic effect on mammalian cell morphology.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据