Highly stereoselective synthesis of aminoglycosides via rhodium-catalyzed and substrate-controlled aziridination of glycals

The flexible installations of a sulfamate ester on a glycal scaffold at C3, C4, or C6 approaching alpha- or beta-aminoglycosides is communicated. A variety of glycal acceptors (O, S, and N) were applied, enhancing the utility of this method as an operationally simple protocol for the stereoselective synthesis of polyfunctionalized alpha- or beta-aminosaccharides.