Synthesis of functionalized H-pyrazolo[5,1-a]isoquinolines via sequential reactions of N '-(2-alkynylbenzylidene)hydrazides

Diversity-oriented synthesis of functionalized H-pyrazolo[5,1-a]isoquinolines via sequential reactions of N'-(2-alkynylbenzylidene)hydrazide is described. Bromine-mediated electrophilic cyclization, Ag-catalyzed alkyne nucleophilic addition, and palladium-catalyzed cross-coupling reaction were involved in the transformation.