期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 7, 期 24, 页码 5137-5145出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/b916305k
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资金
- Arnold and Mabel Beckman Foundation
para-Nitrophenol-tagged sialyl galactosides containing sialic acid derivatives in which the C5 hydroxyl group of sialic acids was systematically substituted with a hydrogen, a fluorine, a methoxyl or an azido group were successfully synthesized using an efficient chemoenzymatic approach. These compounds were used as valuable probes in high-throughput screening assays to study the importance of the C5 hydroxyl group of sialic acid in the recognition and the cleavage of sialoside substrates by bacterial sialidases.
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