期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 6, 期 9, 页码 1540-1543出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/b802459f
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The straightforward synthesis of both enantiomers of cis-5'- hydroxythalidomide, a major metabolite of thalidomide, has been accomplished by enzymatic kinetic resolution of a racemic substrate catalyzed by Pseudomonas stutzeri lipase TL. cis-5'-Hydroxythalidomide shows resistance to racemization ( and epimerization) at physiological pH. A tube formation assay to assess the ability to inhibit angiogenesis revealed that cis-5'-hydroxythalidomides are inactive.
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