期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 6, 期 7, 页码 1197-1200出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/b718734c
关键词
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A simple, two-step synthesis of 4,6-disubstituted pyridazin-3(2H)-ones starting from 2-diethoxyphosphoryl-4-oxoalkanoates and hydrazines is described. The intermediate 4-diethoxyphosphoryl-4,5-dihydropyridazin-3(2H)-ones obtained in this way are used in a Horner-Wadsworth-Emmons olefination of aldehydes to give a variety of disubstituted pyridazin-3( 2H)-ones.
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