Signal amplification by conjugate addition for differential sensing with synthetic pores

The Michael addition of hydrazide amplifiers to short-lived orthoquinone analytes is introduced as a new method of signal amplification and proposed, together with catechol capture by boronate amplifiers, to contribute toward the discrimination of catechol-containing (e.g. epigallocatechin gallate) and catechol-free polyphenols (e.g. resveratrol) with synthetic pores.