期刊
ORAL ONCOLOGY
卷 50, 期 6, 页码 605-610出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.oraloncology.2014.02.016
关键词
Race; Gender; Head; Neck; Carcinoma; Oral cancer; Head and neck cancer
资金
- Eli Lilly and Company
Objectives: Previous retrospective analyses show poor outcomes for African American (AA) patients with head and neck carcinoma (HNC). Such racial disparities are not well understood, and generally studies have been too small to investigate subgroups and interactions related to race. Materials and methods: The longitudinal oncology registry of head and neck carcinoma registry was used to identify patients >= 18 years of age with squamous cell carcinoma of the head and neck, with no baseline metastases, and with an adequate record of survival time. Patient demographic and treatment characteristics were evaluated as a function of race and other known potential confounders of outcome. Associations between patient characteristics, including smoking, stage, performance status, and overall survival (OS) and progression-free survival (PFS) outcomes were also examined. Results: Analysis of OS and PFS confirmed prior reports of inferior outcomes in AA patients vs. Whites with median OS/3-yr rate 41.7 mo/52% in AAs vs. 56.6 mo/70% in Whites (hazard ratio: 1.69 [95% confidence interval: 1.42, 2.01]). The elevated risk for worse OS and PFS in AAs remained, after multivariate adjustment. African American males incurred most of the excess risk compared to AA females. Conclusion: This exploratory study confirmed a worse OS and PFS prognosis for AA patients, and it documents that most of the excess risk occurs in AA males. Future studies should confirm these findings and should investigate biological and other factors that account for such profound differences in outcomes. (c) 2014 Elsevier Ltd. All rights reserved.
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