期刊
ORAL ONCOLOGY
卷 49, 期 6, 页码 576-581出版社
ELSEVIER
DOI: 10.1016/j.oraloncology.2013.01.006
关键词
Fibroblast Growth Factor Receptor 1 FGFR1; Oral tongue squamous cell carcinoma; Oral cancer; Fluorescence in situ hybridisation FISH; Gene amplification; Outcome
Objectives: Novel therapies are required for patients with recurrent or metastatic oral tongue squamous cell carcinoma (OTSCC). Fibroblast Growth Factor Receptor 1 (FGFR1) amplification frequently occurs in squamous cell carcinoma of the lung and represents a novel druggable therapeutic target in this and other malignancies. This study examined the frequency and clinical associations of FGFR1 amplification in OTSCC. Materials and methods: The frequency of FGFR1 amplification determined by fluorescence in situ hybridization was evaluated in a cohort of 123 OTSCC patients. Associations of FGFR1 amplification with clinical characteristics and outcome were determined. Results: FGFR1 gene amplification was present in 9.3% (10/107) of cases and was significantly associated with smoking status (P = 0.03). FGFR1 amplification was seen more commonly in males (9/10 amplified cases male, P = 0.16) and there were no associations with age, stage, T stage, nodal status, alcohol history or performance status (all P > 0.05). Outcome was not significantly different between FGFR1 amplified and non-amplified patients. Conclusions: Copy number variations of the FGFR1 gene occur in a subset of OTSCC with approximately 10% of cases showing amplification of the gene. FGFR1 amplification may represent a therapeutic target in OTSCC. (C) 2013 Elsevier Ltd. All rights reserved.
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