期刊
ORAL ONCOLOGY
卷 48, 期 2, 页码 136-140出版社
ELSEVIER
DOI: 10.1016/j.oraloncology.2011.09.002
关键词
Head and neck cancer; MMP-8; Prognosis; Survival; TIMP-1; Type I collagen; Type III collagen
资金
- Academy of Finland
- Cancer Foundation of Northern Finland, Finnish Cancer Organizations
- Finnish Cultural Foundation
- Finnish Dental Society Apollonia
- Foundation for Laboratory Medicine
- Graduate School of In Vitro Diagnostics
- Ida Montin Foundation
- Scholarship Foundation of the University of Oulu, Oulu University Hospital
- Medical Faculty, University of Oulu
Cancer invasion induces extracellular matrix remodeling and collagen degradation. The aim of this study was to assess whether serum levels of type I and III collagen degradation products were associated with patient survival in head and neck squamous cell carcinoma (HNSCC). A novel enzyme immunoassay was developed for measuring type III collagen N-terminal telopeptide (IIINTP) in human serum samples. In addition, type I collagen C-terminal telopeptide (ICTP), matrix metalloprotease-8 (MMP-8) and tissue inhibitor of metalloproteases-1 (TIMP-1) were assessed in 205 blood samples from HNSCC patients. High levels of serum ICTP and IIINTP and plasma TIMP-1 were associated with poor survival. The concentration of ICTP was associated with levels of IIINTP and TIMP-1. The plasma concentration of MMP-8 was associated with tumor stage, but not with survival or levels of ICTP, IIINTP or TIMP-1 suggesting that other collagenases/proteases are responsible for the cleavage of type I and type III collagens. The rate of type I and type III collagen degradation is associated with patient survival and can be used as a prognostic marker in HNSCC. (C) 2011 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据