期刊
ORAL ONCOLOGY
卷 46, 期 4, 页码 311-316出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.oraloncology.2010.02.001
关键词
Salivary adenoid cystic carcinoma; C-kit; Slug; Invasion; Metastasis; Epithelial-mesenchymal transitions
资金
- National Natural Science Foundation of China [30300391, 30872889]
- Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry [20098-8-2]
The overexpression of c-kit seems to be frequent and specific in salivary adenoid cystic carcinoma (ACC), however, there is little information on correlation between c-kit expression and the invasion and metastasis. Recently, the data showed that Slug, a transcription factor of epithelial-mesenchymal transitions (EMT), is a molecular target that contributes to the biological specificity of c-kit signaling pathway. In this study, the expression of c-kit and Slug was evaluated in two ACC cell lines and 121 patients with ACC. The results of real-time RT-PCR and Western blot showed that ACC-2 and ACC-M cell lines expressed c-kit and Slug mRNA and protein. The immunohistochemical assay in patients demonstrated that positive expression of c-kit and Slug was observed in 108/121 (89.26%) and 87/121 (71.90%) of cases, respectively, and that c-kit and Slug expression was significantly associated with tumor site, TNM stage, histological pattern, perineural invasion, local regional recurrence and distant metastasis of patients with ACC (P<0.05). Furthermore, there was a significant association between the positive expression of c-kit and that of Slug ( P = 0.046). These findings indicated that c-kit/Slug pathway might participate in the invasion and metastasis of salivary ACC. (C) 2010 Elsevier Ltd. All rights reserved.
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