期刊
ORAL ONCOLOGY
卷 44, 期 5, 页码 425-429出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.oraloncology.2007.09.009
关键词
cancer; saliva; diagnostics; mRNA; transcriptome
资金
- NIDCR NIH HHS [R01 DE017170-01A2, R01 DE015970, R01 DE 15970, R01 DE015970-04, R01 DE017170] Funding Source: Medline
Head and neck squamous cell carcinoma (HNSCC) affects almost 1 million people worldwide per year. Despite therapeutic advances the overall survival rate remains low because diagnosis often occurs only at advanced stages with poor prognosis. Like in most cancers, the implementation of an early detection scheme would have a positive impact on this disease. Similarly, as oral cancer has a very high recurrence rate, the early identification of recurrence or second primary tumors is an important challenge. HNSCC detection is currently based on expert clinical examination of the upper aerodigestive tract and histologic analysis of suspicious areas, but it may be undetectable in hidden sites, and unfortunately visual screening for oral lesions is an often neglected part of dental healthcare. Our group is actively pursuing the assembly of a toolbox for the molecular analysis of oral fluid. Here we present our current status utilizing the salivary transcriptome for oral cancer diagnostics. (c) 2007 Elsevier Ltd. All rights reserved.
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