期刊
ORAL DISEASES
卷 21, 期 1, 页码 E51-E61出版社
WILEY
DOI: 10.1111/odi.12264
关键词
drug-induced gingival overgrowth; folic acid; matrix metalloproteins; calcineurin inhibitors; calcium channel blocking agents; phenytoin
资金
- Intramural NIH HHS [ZIA DE000741-01] Funding Source: Medline
Drug-induced gingival overgrowth (DIGO) is a disfiguring side effect of anti-convulsants, calcineurin inhibitors, and calcium channel blocking agents. A unifying hypothesis has been constructed which begins with cation flux inhibition induced by all three of these drug categories. Decreased cation influx of folic acid active transport within gingival fibroblasts leads to decreased cellular folate uptake, which in turn leads to changes in matrix metalloproteinases metabolism and the failure to activate collagenase. Decreased availability of activated collagenase results in decreased degradation of accumulated connective tissue which presents as DIGO. Studies supporting this hypothesis are discussed.
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