期刊
ORAL DISEASES
卷 16, 期 4, 页码 360-364出版社
WILEY
DOI: 10.1111/j.1601-0825.2009.01646.x
关键词
carcinoma; miR-31; marker; oral; plasma; saliva
资金
- National Science Council [NSC96-2628-B-010-033-MY3, 96-2314-B-195-018-MY3]
- Taipei Mackay Hospital [9717]
Backgrounds: Oral squamous cell carcinoma (OSCC) is a worldwide disease. MicroRNAs are endogenously expressed non-coding RNAs that have important biological and pathological functions. miR-31 was found markedly up-regulated in OSCC and several other malignancies. However, miR-31 expression was also down-regulated in the metastasis process of breast carcinoma. Materials and methods: Using quantitative RT-PCR analysis, we identified plasma miR-31 in OSCC patients (n = 43) and case controlled individuals (n = 21). Nine OSCC patients saliva were also analyzed. The Mann-Whitney test and Wilcoxon matched pairs test were used to compare the differences among the various clinical variants. Results: miR-31 in plasma was significantly elevated in OSCC patients relative to age and sex-matched control individuals. This marker yielded a receiver operating characteristic curve area of 0.82 and an accuracy of 0.72 defined by leave-one-out cross-validation. In addition, the plasma miR-31 in patients was remarkably reduced after tumor resection suggesting that this marker is tumor associated. Our preliminary analysis also demonstrated the feasibility of detecting the increase of miR-31 in patient's saliva. Conclusion: This study concluded that plasma miR-31 could be validated a marker of OSCC for diagnostic uses.
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