期刊
ORAL DISEASES
卷 17, 期 3, 页码 298-303出版社
WILEY
DOI: 10.1111/j.1601-0825.2010.01740.x
关键词
stage I oral squamous cell carcinoma; tumour thickness; diagnosis; clinical appearance
资金
- Ricerca Sanitaria Finalizzata Regione Piemonte
- Compagnia di San Paolo, Torino, Italy
Background: This study aimed to analyse a case series of microinvasive (tumour thickness < 4 mm) stage I oral squamous cell carcinoma (OSCC), with an emphasis on the clinical features of the tumours. Methods: In total, 32 microinvasive and 67 non-microinvasive stage I lesions, which had been surgically treated, were retrospectively studied and compared. The data analysed included gender, age, risk habits, clinical appearance, lesion site, symptoms, nodal involvement and outcome. Results: The clinical features of microinvasive lesions meant that, more often than not, they resembled premalignant lesions (P = 0.008), and diagnosis was mainly based on accurate clinical examination rather than the presence of symptoms (P = 0.029). During a median follow-up of 4.5 years, one nodal involvement and one cancer-related death were observed in patients with microinvasive lesions. A significantly higher (P = 0.044) level of nodal involvement was observed in the non-microinvasive lesion group. Conclusions: Stage I OSCC has a favourable prognosis overall, but nodal recurrence is more common in non-microinvasive cancers. As microinvasive lesions tend to present clinically as premalignant lesions, accurate clinical examination is essential if misdiagnosis of early lesions is to be avoided.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据