期刊
THIN SOLID FILMS
卷 596, 期 -, 页码 83-86出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.tsf.2015.08.060
关键词
Biofilm; Chitosan; Bacteria; Titanium; Infection; Implant; Biomaterial; Prevention
类别
资金
- FedEx institute of Technology Innovation Fund [SB-2]
Porous calcium phosphate microspheres have been modified to contain nanoparticles of silver to provide both osteoconductive and antimicrobial components to implant coatings. These microspheres have been mixed with chitosan and bonded to titanium via alkyloxysilane reaction. Silver concentration on calcium phosphate microspheres was varied from 0 to 50% and microspheres were loaded at 30 wt.% within chitosan coatings. Increasing concentrations of silver loaded on calcium phosphate microspheres within the chemically bound coating reduces bacterial viability by up to 90% in both anaerobic and aerobic pathogenic microorganisms, including Staphylococcus aureus, Prevotella denticola, and Porphyromonas gingivalis. This novel coating could reduce the incidence of infection in orthopaedic and dental implant applications. (C) 2015 Elsevier B.V. All rights reserved.
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