期刊
OPTICS LETTERS
卷 39, 期 17, 页码 5192-5195出版社
OPTICAL SOC AMER
DOI: 10.1364/OL.39.005192
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资金
- NIH [DP1 EB016986, R01 CA186567, R01 CA159959]
- NSF [1255930]
- Microphotoacoustics, Inc.
- Endra, Inc.
- Direct For Biological Sciences
- Div Of Biological Infrastructure [1255930] Funding Source: National Science Foundation
Compared with visible light (700 nm), near-infrared light (1400 nm) undergoes weaker optical attenuation in biological tissue; thus, it can penetrate deeper. Herein, we demonstrate near-infrared optical-resolution photoacoustic microscopy (NIR-OR-PAM) with 1046 nm illumination. A penetration depth of 3.2 mm was achieved in chicken breast tissue ex vivo using optical fluence within the American National Standards Institute (ANSI) limit (100 mJ/cm(2)). Beyond similar to 0.6 mm deep in chicken breast tissue, NIR-OR-PAM has shown finer resolution than the visible counterpart with 570 nm illumination. The deep imaging capability of NIR-OR-PAM was validated in both a mouse ear and a mouse brain. NIR-OR-PAM of possible lipid contrast was explored as well. (C) 2014 Optical Society of America
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