期刊
OPTICS LETTERS
卷 36, 期 7, 页码 1062-1064出版社
Optica Publishing Group
DOI: 10.1364/OL.36.001062
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资金
- National Science Foundation (NSF) [0852742]
- Div Of Biological Infrastructure
- Direct For Biological Sciences [0852742] Funding Source: National Science Foundation
Optical aberrations due to the inhomogeneous refractive index of tissue degrade the resolution and brightness of images in deep-tissue imaging. We introduce a confocal fluorescence microscope with adaptive optics, which can correct aberrations based on direct wavefront measurements using a Shack-Hartmann wavefront sensor with a fluorescent bead used as a point source reference beacon. The results show a 4.3 x improvement in the Strehl ratio and a 240% improvement in the signal intensity for fixed mouse tissues at depths of up to 100 mu m. (C) 2011 Optical Society of America
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