期刊
OPTICS LETTERS
卷 36, 期 7, 页码 1236-1238出版社
OPTICAL SOC AMER
DOI: 10.1364/OL.36.001236
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资金
- National Institutes of Health (NIH) [R01 EB000712, R01 EB008085, R01 CA134539, U54 CA136398, R01 EB010049, 5P60 DK02057933]
- Microphotoacoustics, Inc.
- Endra, Inc.
Although ultrasound arrays have been exploited in photoacoustic imaging to improve imaging speed, ultrasound-array-based optical-resolution photoacoustic microscopy (OR-PAM) has never been achieved previously to our knowledge. Here we present our development of multifocal OR-PAM using a microlens array for optical illumination and an ultrasound array for photoacoustic detection. Our system is capable of imaging hemoglobin concentration and oxygenation in individual microvessels in vivo at high speed. Compared with a single focus, multiple foci reduce the scanning load and increase the imaging speed significantly. The current multifocal system can acquire 1000 x 500 x 200 voxels at similar to 10 mu m lateral resolution within 4 min. (C) 2011 Optical Society of America
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