期刊
OPTICS LETTERS
卷 35, 期 9, 页码 1314-1316出版社
OPTICAL SOC AMER
DOI: 10.1364/OL.35.001314
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资金
- National Science Foundation (NSF) [0431024, 0854249, 0915966]
- Direct For Computer & Info Scie & Enginr
- Division of Computing and Communication Foundations [0915966] Funding Source: National Science Foundation
- Direct For Computer & Info Scie & Enginr
- Division of Computing and Communication Foundations [0431024] Funding Source: National Science Foundation
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [0854249] Funding Source: National Science Foundation
We demonstrate the in vivo reconstruction of all fluorescence resonance energy transfer (FRET) parameters, including the nanometer donor-acceptor distance, in a mouse. The FRET chemical targets cancer cells, and on internalization, the acceptor is released, in lieu of a targeted anticancer drug in chemotherapy. Our method provides a new vehicle for studying disease by imaging FRET parameters in deep tissue. (C) 2010 Optical Society of America
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