期刊
OPTICS LETTERS
卷 35, 期 23, 页码 4018-4020出版社
OPTICAL SOC AMER
DOI: 10.1364/OL.35.004018
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- National Institutes of Health (NIH) [7R21EB008800-02]
- Juvenile Diabetes Research Foundation [5-2009-498]
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R21EB008800] Funding Source: NIH RePORTER
We investigated the feasibility of simultaneously imaging two distinctive molecular contrasts provided by the absorbed photons in biological tissues with a single light source. The molecular contrasts are based on two physical effects induced by the absorbed photons: photoacoustics (PA) and autofluorescence (AF). In an integrated multimodal imaging system, the PA and AF signals were detected by a high-sensitivity ultrasonic transducer and an avalanche photodetector, respectively. The system was tested by imaging ocular tissue samples, including the retinal pigment epithelium and the ciliary body. The acquired images provided information on the spatial distributions of melanin and lipofuscin in these samples. (C) 2010 Optical Society of America
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