期刊
OPTICS LETTERS
卷 35, 期 5, 页码 700-702出版社
OPTICAL SOC AMER
DOI: 10.1364/OL.35.000700
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资金
- NIH [R01-CA75289-13]
- AFOSR [FA9550-07-1-0014]
- MFELP [FA9550-07-1-0101]
- NSERC
- Heritage Scholarship Fund
- CIMIT
- NSCT
We demonstrate photothermal optical coherence tomography (OCT) imaging in highly scattering human breast tissue ex vivo. A 120 kHz axial scan rate, swept-source phase-sensitive OCT system at 1300 nm was used to detect phase changes induced by 830 nm photothermal excitation of gold nanoshells. Localized phase modulation was observed 300-600 mu m deep in scattering tissue using an excitation power of only 22 mW at modulation frequencies up to 20 kHz. This technique enables integrated structural and molecular-targeted imaging for cancer markers using nanoshells. (C) 2010 Optical Society of America
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