期刊
OPTICS LETTERS
卷 34, 期 24, 页码 3899-3901出版社
OPTICAL SOC AMER
DOI: 10.1364/OL.34.003899
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资金
- National Institutes of Health (NIH) [R01 NS48283, R01 NS67905, P01 NS32636, R01 EB000712, R01 NS46214, R01 EB008085, U54 CA136398]
We report optical-resolution photoacoustic microscopy (OR-PAM) for in vivo imaging of amyloid plaques in an Alzheimer's disease mouse model. Validation using conventional fluorescence microscopy and multiphoton microscopy shows that OR-PAM has sufficient sensitivity and spatial resolution to identify amyloid plaques in living brains. In addition, with dual-wavelength OR-PAM, the three-dimensional morphology of amyloid plaques and the surrounding microvasculature are imaged simultaneously through a cranial window without angiographic contrast agents. OR-PAM, capable of providing both exogenous molecular contrast and endogenous hemoglobin contrast, has the potential to serve as a new technology for in vivo microscopic observations of cerebral plaque deposits. (C) 2009 Optical Society of America
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