期刊
OPTICS LETTERS
卷 34, 期 12, 页码 1816-1818出版社
OPTICAL SOC AMER
DOI: 10.1364/OL.34.001816
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- Engineering and Physical Sciences Research Council (EPSRC) [EP/E0131198/1]
- Biotechnology and Biological Sciences Research Council (BBSRC) [BB/D001013/1]
- UK Research Councils
- European Union Marie Curie [PIEF-GA-2008-220901]
- Councils United Kingdom
- BBSRC [BB/D001013/1] Funding Source: UKRI
- EPSRC [EP/E013198/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/D001013/1] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [EP/E013198/1] Funding Source: researchfish
By detecting the transient four-wave mixing from gold nanoparticles in resonance with their surface plasmon, we demonstrate a multiphoton imaging modality suited for cell microscopy. Four-wave mixing is measured free from background using a three-beam excitation geometry and heterodyne detection. We achieve a spatial resolution of 140 mn in-plane and 470 nm in the axial direction, surpassing the one-photon diffraction limit. With this technique, high-contrast photostable imaging of Golgi structures is demonstrated in HepG2 cells labeled with gold nanoparticles of 10 mn and 5 nm diameter. (C) 2009 Optical Society of America
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