We present highly sensitive refractometers based on a long-period grating in a large-mode-area photonic crystal fiber (PCF). The maximum sensitivity is 1500 nm/refractive index unit at a refractive index of 1.33, to our knowledge the highest reported for any fiber grating. The minimal detectable index change is 2 X 10(-5). The high sensitivity is obtained by infiltrating the sample into the holes of the PCF to give a strong interaction between the sample and the probing field. (C) 2008 Optical Society of America.
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