期刊
OPTICS EXPRESS
卷 20, 期 3, 页码 2587-2597出版社
OPTICAL SOC AMER
DOI: 10.1364/OE.20.002587
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类别
资金
- European Union
- TUBITAK [109E301, 107A004, 107A012]
- DPT
- Turkish Academy of Sciences
We present a label-free, optical nano-biosensor based on the Localized Surface Plasmon Resonance (LSPR) that is observed at the metal-dielectric interface of silver nano-disk arrays located periodically on a sapphire substrate by Electron-Beam Lithography (EBL). The nano-disk array was designed by finite-difference and time-domain (FDTD) algorithm-based simulations. Refractive index sensitivity was calculated experimentally as 221-354 nm/RIU for different sized arrays. The sensing mechanism was first tested with a biotin-avidin pair, and then a preliminary trial for sensing heat-killed Escherichia coli (E. coli) O157:H7 bacteria was done. Although the study is at an early stage, the results indicate that such a plasmonic structure can be applied to bio-sensing applications and then extended to the detection of specific bacteria species as a fast and low cost alternative. (C) 2012 Optical Society of America
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