期刊
OPTICS EXPRESS
卷 18, 期 18, 页码 18625-18632出版社
OPTICAL SOC AMER
DOI: 10.1364/OE.18.018625
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资金
- Arizona Cancer Center [IRG-7400128]
- NSF [0853618]
- Advanced Research Institute for Biomedical Imaging (ARIBI)
- Technology Research Infrastructure Fund (TRIF)
- Directorate For Engineering
- Div Of Chem, Bioeng, Env, & Transp Sys [0853618] Funding Source: National Science Foundation
- Directorate For Engineering
- Div Of Chem, Bioeng, Env, & Transp Sys [1158851] Funding Source: National Science Foundation
A clinical ultrasound scanner and 14 MHz linear array collected real-time photoacoustic images (PAI) during an injection of gold nanorods (GNRs) near the region of a mature PC-3 prostate tumor in mice implanted with a skin flap window chamber. Three dimensional spectroscopic PAI (690-900nm) was also performed to investigate absorption changes near the tumor and enhance specific detection of GNRs. Whereas GNRs improved PAI contrast (+ 18 dB), the photoacoustic spectrum was consistent with the elevated near infrared absorption of GNRs. The versatile imaging platform potentially accelerates development of photoacoustic contrast agents and drug delivery for cancer imaging and therapy. (C) 2010 Optical Society of America
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