期刊
OPTICS EXPRESS
卷 17, 期 5, 页码 3855-3860出版社
OPTICAL SOC AMER
DOI: 10.1364/OE.17.003855
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- Sungkyunkwan University
We demonstrate a sensitive DNA biosensor based on a long period grating (LPG) formed by a photolithograph process on the surface of a side-polished fiber. The biomolecules of the biosensor were immobilized on the silica surface between LPG patterns. The resonance wavelength was red-shifted after the binding of the poly-L-lysine, probe ssDNA and target ssDNA to the sensor surface. The overall wavelength shift after the successful DNA hybridization was 1.82 nm. The proposed LPG-based DNA biosensor is similar to 2.5 times more sensitive than the previously reported fiber grating-based DNA biosensors. (C) 2009 Optical Society of America
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