期刊
OPTICS EXPRESS
卷 16, 期 12, 页码 8594-8603出版社
OPTICAL SOC AMER
DOI: 10.1364/OE.16.008594
关键词
-
类别
资金
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [0852417] Funding Source: National Science Foundation
Micromechanical properties of biological cells are crucial for cells functions. Despite extensive study by a variety of approaches, an understanding of the subject remains elusive. We conducted a comparative study of the micromechanical properties of cultured alveolar epithelial cells with an oscillatory optical tweezer-based cytorheometer. In this study, the frequency-dependent viscoelasticity of these cells was measured by optical trapping and forced oscillation of either a submicron endogenous intracellular organelle (intra-cellular) or a 1.5 mu m silica bead attached to the cytoskeleton through trans-membrane integrin receptors (extra-cellular). Both the storage modulus and the magnitude of the complex shear modulus followed weak power-law dependence with frequency. These data are comparable to data obtained by other measurement techniques. The exponents of power-law dependence of the data from the intra- and extracellular measurements are similar; however, the differences in the magnitudes of the moduli from the two measurements are statistically significant. (c) 2008 Optical Society of America.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据