期刊
OPTICS EXPRESS
卷 16, 期 1, 页码 219-224出版社
OPTICAL SOC AMER
DOI: 10.1364/OE.16.000219
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- NIGMS NIH HHS [T32-GM008347] Funding Source: Medline
Surface plasmon resonance (SPR) imaging is a powerful technique for high-throughput, real-time, label-free characterization of molecular interactions in a microarray format. In this paper, we demonstrate SPR imaging with nanohole arrays illuminated by a laser source. Periodic nanoholes couple incident photons into SPs, obviating the need for the prism used in conventional SPR instruments, while a laser source provides the intensity, stability and spectral coherence to improve the detection sensitivity. The formation of a self-assembled monolayer of alkanethiolates on gold changed the laser transmission by more than 35%, and binding kinetics were measured in parallel from a 5 x 3 microarray of nanohole sensors. These results demonstrate the potential of nanohole sensors for high-throughput SPR imaging on microarrays. (c) 2008 Optical Society of America.
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