期刊
TETRAHEDRON-ASYMMETRY
卷 26, 期 2-3, 页码 109-117出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetasy.2014.12.009
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资金
- National Science Foundation of China [21372002, 21232007]
- Open Foundation of Jiangsu Key Laboratory [K201314]
- PAPD of Jiangsu Province
- Qing Lan Project
The first catalytic asymmetric styrene hydroarylation reaction has been established via the enantioselective Friedel-Crafts alkylations of phenylhydrazones with o-hydroxyl styrenes under the catalysis of a chiral phosphoric acid as an organocatalyst, leading to the construction of a chiral 1,1-diarylethane scaffold with high enantioselectivity (up to 89% ee). The investigation on the activation mode suggested that the two reactants, o-hydroxyl styrenes and phenylhydrazones, were simultaneously activated by the catalyst via multiple hydrogen-bonds. The remote activation of the hydrazone functionality by a dual hydrogen-bonding interaction with the catalyst contributed greatly to the hydroarylation reaction of the o-hydroxyl styrenes. (C) 2014 Elsevier Ltd. All rights reserved.
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