Addition of a carbamoylsilane to N-sulfonylimines: direct synthesis of α-(N-sulfonyl)amino-N-methoxymethyl-N-methylamides

N-Methoxymethyl-N-methylcarbamoyl(trimethyl)silane reacted with N-sulfonylimines in anhydrous benzene under catalyst-free conditions to afford alpha-(N-sulfonyl)amino-N-methoxymethyl-N-methylamides in good to excellent yields (71-95%). Furthermore, after acid hydrolysis at room temperature, the corresponding alpha-(N-sulfonyl)amino secondary amides can be formed. (C) 2015 Elsevier Ltd. All rights reserved.