β-Cyclodextrin as a supramolecular catalyst for the synthesis of dihydropyrano[2,3-c]pyrazole and spiro[indoline-3,4′-pyrano [2,3-c]pyrazole] in aqueous medium

Supramolecular beta-cyclodextrin (beta-CD) as a highly efficient, biodegradable, and reusable catalyst for the synthesis of pyranopyrazole derivatives is investigated via a one-pot four component reaction of aldehydes and isatins, hydrazine hydrate, malononitrile, and beta-keto ester in H2O-EtOH (9:1) at 80 degrees C for first time under neutral conditions. (C) 2015 Elsevier Ltd. All rights reserved.