期刊
TETRAHEDRON LETTERS
卷 56, 期 24, 页码 3790-3792出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2015.04.070
关键词
2-Phenylquinolines; Alkyne; Aldehydes; Ketones; Electronic properties
资金
- Science Foundation of Nanyang Normal University [ZX2013026]
- National Natural Science Foundation of China [21302105]
- Research fund for the key scientific research program of Henan Educational Committee [15A150021]
A facile and economic method for the construction of 2-substituted quinolines by AgOTf-catalyzed 2-aminobenzyl alcohol and alkyne/ketone or 2-aminophenethyl alcohol and aldehyde has been developed. The electronic properties of the substituents on the alkyne, ketone, and aldehyde were investigated. It was found that molecules with both electron-donating and -withdrawing substituents were perfectly suitable substrates for this transformation, and the expected products were obtained in moderate to excellent yields. Moreover, the use of inexpensive starting materials and environmentally benign oxidants makes this atom efficient method particularly attractive. (C) 2015 Elsevier Ltd. All rights reserved.
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