期刊
TETRAHEDRON LETTERS
卷 56, 期 23, 页码 3385-3389出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2015.01.025
关键词
Antibiotic; Carbapenem; beta-Lactam; Silyl enol ether; Lewis acid
资金
- NIAID NIH HHS [R15 AI109624, R41 AI102507] Funding Source: Medline
A diastereoselective process for the formation of intermediates suitable for the preparation of Cl substituted carbapenems was developed. The process is readily scalable and does not involve organometallics or strong bases such as LDA. (C) 2015 Elsevier Ltd. All rights reserved.
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