期刊
TETRAHEDRON LETTERS
卷 56, 期 23, 页码 3046-3051出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2014.11.085
关键词
Arylation; Silyl enol ether; Quinone monoacetal; Substitution; alpha-Aryl carbonyl compound
资金
- Grants-in-Aid for Scientific Research [24689002, 14J12158, 26620036] Funding Source: KAKEN
Quinone monoacetals (QMAs) were found to be convenient substrates for a unique arylation reaction of enol silyl ethers. This arylation process of QMAs typically proceeds through the acetal activation of the QMAs by a hydrogen-bond donor solvent, such as a fluoroalcohol, for the initiating step. The silyl transfer from silyl enol ethers to the carbonyl oxygen of the QMAs appears to be involved in the C-C coupling step, followed by QMA aromatization. By this method, valuable alpha-aryl carbonyl compounds containing o-phenol moieties can be obtained directly under mild conditions without lactone formation. (C) 2014 Elsevier Ltd. All rights reserved.
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