期刊
TETRAHEDRON LETTERS
卷 56, 期 10, 页码 1280-1282出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2015.01.161
关键词
Amides; Acid; Deprotection; Dealkylation
Tertiary amides containing an N-isopropyl group were selectively deprotected by heating in methanesulfonic acid. The N-isopropyl group was removed selectively in the presence of other groups on the amide nitrogen such as methyl, primary alkyl, or aryl. The putative isopropyl cation was trapped by Friedel-Crafts alkylation of anisole when the latter was included as a co-solvent. (C) 2015 Elsevier Ltd. All rights reserved.
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