Retinal Vasculopathy in Fanconi Anemia

The authors present a case of Fanconi anemia with bilateral rapid onset retinal neovascularization and vitreous hemorrhage. The patient developed branch retinal vein occlusion in the left eye complicated by vitreous hemorrhage and was treated conservatively with intravitreal hyaluronidase injection. He declined vitrectomy and his visual acuity deteriorated to no perception of light. On follow-up, the right eye was noted to have clinical and angiographic evidence of sheathed vessels, an isolated large frond of neovascularization associated with areas of capillary nonperhision. Panretinal photocoagulation and vitrectomy were performed with stabilization of vasculopathy and visual acuity. This case illustrates rapid onset peripheral occlusive vasculopathy with an atypical large isolated frond of neovascularization in a patient with Fanconi anemia resulting in blindness in one eye. Patients with Fanconi anemia would benefit from close and regular ophthalmological review. [Ophthalmic Surg Lasers Imaging 2009;40:498-500.]