New solid phase submonomer synthesis of arylopeptoid oligomers using reductive amination

Herein, we describe a new methodology for the solid phase submonomer synthesis (SPSS) of arylopeptoids using a reductive amination reaction as the key step instead of a nucleophilic substitution reaction, which is generally used in conventional SPSS of peptoids. The new SPSS enables easy access to arylopeptoid oligomers in which phenyl side groups are directly attached to the aromatic main chain. (C) 2015 Elsevier Ltd. All rights reserved.